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Month: March 2007

Bipolar Disorder and the Circadian Rhythm

Circadian Rhythm Linked to bipolar disorder TUESDAY, March 20, 2007 (HealthDay News) — A gene involved in regulating circadian rhythms — daily rhythms, including the wake/sleep cycle — may also play a central role in the manic phase of bipolar disorder. Mice with a particular mutation in the CLOCK gene, which is central in regulating circadian rhythms, displayed behavior very similar to manic behavior in humans. Given lithium, a drug used to treat bipolar disorder, the mice returned to many of their normal behaviors. The findings could serve as a launching point for further research into bipolar disorder, whose mechanisms continue to elude scientists. “It gives us a really nice model of mania to be able to study how mania develops and how the treatments for mania work, because a lot of the actions of mood stabilizers have been a mystery,” said Colleen McClung, study senior author and assistant professor of psychiatry at the University of Texas Southwestern Medical Center at Dallas. “Bipolar has been difficult to study.” David J. Earnest, a professor of neuroscience and experimental therapeutics at Texas A&M Health Science Center College of Medicine, added: “It really does provide something beyond an associative or correlative observation that circadian rhythms are disturbed when patients are experiencing bipolar disorder. In this animal model, this mutation in the CLOCK gene produces behavioral patterns which are very similar to bipolar...

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Retractable Depression: Fact Or Fiction?

Is there such a thing as retractable depression? One must first study the root meaning of retractable. Retractable depression has a connotation that the sufferer is able to ‘pull’ out of in and go back in to the depression state, at free will. Nothing could be further from the truth. Depression sufferers do not generally have the ability to ‘snap out of it’ or they would gladly do so. You don’t very often hear of someone who is suffering from depression that are happy about the diagnosis or suspected diagnosis. Depression is a state that promotes negative feelings about...

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